Erdbrügger Laboratory
Division of Nephrology
The
Erdbrügger Lab is interested in studying the fascinating role of extracellular vesicles (EVs) as novel bio-markers and bio-activators in kidney disease and high blood pressure. EVs are a very heterogeneous group of small vesicles which can derive from all cells in the body either by secretion or blebbing of cell membranes. Inititally thought as “cell trash” EVs are emerging as novel communicators in health and disease. Because of their small size (submicron) and heterogeneous nature our second focus of research is optimization of EV isolation and characterization. See links to our publications for more details.
Latest Publications:
1.Martens-Uzunova ES, Blijdorp CJ, Burger D, Erdbrügger U, Llorente A. Urinary Extracellular Vesicles in Urology: Current Successes and Challenges Ahead. Eur Urol. 2022 Jan;81(1):127-128.
2. Erdbrügger U et al., Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles. J Extracell Vesicles. 2021 May;10(7):e12093.
3.La Salvia S, Musante L, Lannigan J, Gigliotti JC, Le TH, Erdbrügger U. T cell-derived extracellular vesicles are elevated in essential HTN. Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F868-F875.
4.La Salvia S, Gunasekaran PM, Byrd JB, Erdbrügger U. Extracellular Vesicles in Essential Hypertension: Hidden Messengers. Curr Hypertens Rep. 2020 Sep 3;22(10):76.
5. Musante L, Bont ha SV, La Salvia S, Fernandez-Piñeros A, Lannigan J, Le TH, Mas V, Erdbrügger U. Rigorous characterization of urinary extracellular vesicles (uEVs) in the low centrifugation pellet - a neglected source for uEVs. Sci Rep. 2020 Feb 28;10(1):3701.
Full Publication Lists
Dr. Uta Erdbrügger
Our research is supported by
